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中药超微粉碎市场上的要求
来源:http://www.jnjuncheng.com/news/30.html发布时间:2017-01-10
1.安全方面。生产中要求选定的设备应稳定性好、对产品无污染,同时要注意粉体的自燃问题。
1 security aspects. Production requirements of the selected equipment should be good stability, no pollution to the product, at the same time should pay attention to the problem of powder spontaneous combustion.
2.粉碎程度方面。中药主要为植物药、动物药、矿物药,其中植物药根据药用部位又分根、茎、叶、花、果实、种子、树皮等,且成分十分复杂,并不是所有的药物均适宜进行超细粉碎处理,也不是粉末越细越好。如含挥发油的药物,超细粉碎制备粉体时有可能损失挥发油成分,影响药效,因此需认真考察。
2 degree of grinding. Traditional Chinese medicine is mainly plant medicine, animal medicine, mineral medicine, medicine and medicinal parts of the plant according to the root, stem and leaf, flower, fruit, seeds and bark, and the composition is very complex, not all drugs are suitable for superfine grinding processing, powder is not as small as possible. Such as volatile oil containing drugs, ultrafine powder preparation is likely to lose the volatile oil components, affecting the efficacy, it is necessary to carefully investigate.
3 in vivo adhesion. Due to the small size of the biological particles, whether it will adhere to the gastrointestinal mucosa, the impact of gastrointestinal motility, mucosal absorption, gastrointestinal hormone secretion, cell and cell membrane function and other issues remain to be investigated. Jiangxi University of Traditional Chinese Medicine, and other Chinese herbal medicine ultrafine powder in the clinical investigation of the phenomenon has not been found in the adhesion and other undesirable phenomena, but it still needs further large-scale clinical investigation.
4.毒副反应方面。含毒性成分的药物,超细粉碎有可能使其毒性增加,影响用药安全性。生物粉碎制剂溶出度增加,使有效成分与其他成分的溶出同时增加,中药细胞破壁后细胞内活性成分是否会发生化学变化而在肾、肝、血液、心血管、神经系统等器官或系统引起新的不良反应或毒副作用,应仔细考察,同时必须加强药理和临床研究。 差也较大。
4 toxic side effects. It is possible to increase the toxicity of the drugs containing toxic components, which may affect the safety of drugs. Biological grinding degree increased dissolution preparation, the effective components and other components of the dissolution increases at the same time, traditional Chinese medicine active components of cell wall breaking whether intracellular chemical changes may occur in the kidney, liver, blood, cardiovascular system, nervous system and other organs or cause new adverse reaction or side effects, should be carefully investigated, at the same time we must strengthen the pharmacological and clinical research. Difference is also larger.
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