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超细粉体技术在中药制剂中能起到什么作用?

有利于进步药物的生物使用率
Progressive drug bioavailability
中药材绝大部分来源于动植物。一般情况下,药用有效成分首要存在于细胞内,在细胞完整无损时有效成分只有透过细胞膜(壁)后才能被使用。应用超细粉体技能可使药材细胞破壁。选用超细粉体技能得到的原生药超微粉体原料,药材的破壁率大于95%,大大进步药物的生物使费用和效果。中药进行超细破坏实现药材细胞破壁后,细胞内的有效成分被露出出来,因而药效大幅进步且起效敏捷。特别是关于质地坚固细密的药材,超细破坏破壁后可免除溶剂穿透细胞壁进入细胞内将药效成分溶出的漫长进程和妨碍,故存在更有利于缩短提取时间、下降用量的可能性。
The vast majority of Chinese medicinal materials come from animals and plants. In general, the active ingredients of medicines mainly exist in the cells. When the cells are intact, the active ingredients can only be used through the cell membrane (wall). The application of superfine powder technique can break the cell wall of medicinal materials. The wall-breaking rate of the raw material is more than 95%, which greatly improves the cost and effect of the medicine. After ultrafine destruction of traditional Chinese medicines to break the cell wall, the effective components in the cells are exposed, so the efficacy of traditional Chinese medicines is greatly improved and quick. Especially for the medicinal materials with strong and fine texture, the long process and obstacle of dissolving the effective ingredients into cells by breaking through the cell wall can be avoided after ultra-fine destruction. Therefore, it is more conducive to shorten the extraction time and reduce the dosage.
有利于进步药效
Benefiting the Progress of Pharmacodynamics
在超细粉体进程中,经操控可不产生过热现象,一起破坏速度较快,有利于保存生物活性成分,从而进步药效。
中药超细粉碎机
In the process of ultrafine powder, it can not produce overheating phenomenon by manipulation. Together, the destruction speed is faster, which is conducive to the preservation of bioactive ingredients and the improvement of pharmacodynamics.
有利于节约资源
Be conducive to saving resources
选用一般的机械破坏,纤维性较强的药材在破坏进程中会产生大量残渣,形成原药材的浪费。而经超细粉体技能处理的药材,可不再经浸提等处理,简化了提取进程,最大极限地使用原药材。因而,关于一些贵重药材及一些来源稀疏、价格昂贵的保健补养中药,应用超细粉体技能将其加工成超细粉体,可以减少资源浪费,进步吸收率与效果。
In the process of destroying, a large amount of residue will be produced and the waste of raw medicinal materials will be formed. However, the medicinal materials treated by superfine powder technology can no longer be treated by extraction, which simplifies the extraction process and maximizes the use of the original medicinal materials. Therefore, for some valuable medicinal materials and some health tonic medicines with sparse and expensive sources, the application of ultra-fine powder technology to process them into ultra-fine powder can reduce the waste of resources, improve the absorption rate and effect.
关于固体制剂的质量操控,分量差异、混合均匀度、片剂的强度等多与粉体操作有关,而崩解时限、溶出度和生物使费用则与药物处方中各种物料的粉体性质有关。因为中药超细粉体的特色,在超细粉体技能进程还存在诸多影响因素,同一设备、同一破坏工艺要到达同一细度超细粉体的要求还有难度。事实上,并非所有药物都是粒度越小越好,应经过试验确定单味药材和复方制剂的最佳粒径.
As for the quality control of solid preparations, the difference of components, the uniformity of mixing and the strength of tablets are related to the powder operation, while the disintegration time, dissolution rate and biological cost are related to the powder properties of various materials in the drug prescription. Because of the characteristics of ultra-fine powder of traditional Chinese medicine, there are still many factors affecting the skill process of ultra-fine powder. It is difficult for the same equipment and the same destructive process to reach the requirements of the same ultra-fine powder. In fact, not all medicines are better with smaller particle size. It is necessary to determine the optimum particle size of single medicines and compound preparations through experiments.
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